First, the Kambo which dried on the wooden stick is reconstituted with a few drops of water and rolled into a small ball with the edge of a clean knife. 

With a thin (3-5mm) vine "Tamishi" is used to lightly burn the top layer of skin. These are small and easy to endure and no blood is drawn. This opens the "gateway", preparing the body to receive the medicine via the Lymphatic system. The location of these burns will be based on the type of treatment.

 

If it is your 1st Kambo treatment, or you’ve had Kambo before but taken some time off, you will receive a test point. A single Kambo dot is placed on 1 of the burn points and your reaction to the medicine will be observed with careful attention given to your breathing, heart rate, blood pressure and skin reaction. Assuming the test point goes well the rest of your remaining points will be added and your full treatment will commence.
 

The effect is immediate, as it runs in the body through the lymphatic system. The body becomes warm and the heart beats faster than normal as it scans your body. until the person vomits the water they had been drinking in advance to aid in the removal of toxins.. All this lasts only about 15-20 minutes.

Your general goal is to have the kambo clean your body of impurities and deposit them in your stomach for you to purge thus removing the toxins.